电合成和电催化促进电化学脱芳构化螺环化发展

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翻译 In summary, the recent resurgence of electrosynthesis and electrocatalysis dramatically promotes the development of electrochemical dearomative spirocyclization. Compared with conventional approaches, electrochemical methods exhibit high efficiency, good functional group tolerance, and more opportunities for exploring novel reactivity most notably without using toxic and harmful chemical redox reagents. To this end, novel three-dimension spirocyclic architectures are generated and in-depth mechanistic insights are established, paving the way for the future development and diverse applications of the electrochemical dearomative spirocyclization. The inclusion of continuous-flow electrolysis[65] further enables ready accessibility of scaled production of such kinds of value-added compounds. However, opportunities and challenges still remain. First, besides phenols, electrochemical dearomative spirocyclization of other aromatics and heteroaromatics awaits more explorations,

回答:

总之,电合成和电催化的近期复兴极大地促进了电化学脱芳构化螺环化反应的发展。与传统方法相比,电化学方法表现出高效性、良好的官能团耐受性,并且在不使用有毒有害的化学氧化还原试剂的情况下,提供了更多探索新反应性的机会。为此,生成了新颖的三维螺环结构,并建立了深入的机制见解,为电化学脱芳构化螺环化反应的未来发展和多样化应用铺平了道路。连续流电解的引入进一步使得这种增值化合物的规模化生产变得更加容易。然而,机遇和挑战仍然存在。首先,除了苯酚之外,其他芳香族化合物和杂芳香族化合物的电化学脱芳构化螺环化反应仍需更多